A study of the molecular mechanisms underlying the transmission and expression of genes. DNA replication and recombination, RNA synthesis and processing, and protein synthesis and modification will be examined. Both prokaryotic and eukaryotic systems will be analyzed, with an emphasis upon the regulation of gene expression. Application of modern molecular methods to biomedical problems will also be considered.
Structure and function of biologically important molecules and their role(s) in life processes. Protein conformation, enzymatic mechanisms and selected metabolic pathways will be analyzed. Additional topics may include: nucleic acid conformation, DNA/protein interactions, signal transduction and transport phenomena. Offered jointly by the Departments of Biology and Chemistry.
Metals are required for the function of about one third of all proteins and are involved in vital biological processes such as photosynthesis, respiration, gene regulation, DNA replication and repair, signal transduction, and antioxidant defense. However, essential metals are potentially toxic due to the same properties that make them indispensable. To cope with such a paradox, metals must be tightly regulated.
This advanced seminar focuses on the molecular and cellular biology of metals. Topics of discussion include metal homeostasis strategies (e.g. import/export, chelation, subcellular compartmentalization), metal cofactors of biochemical processes, inherited metal metabolism disorders, and genetics of hyperaccumulators. We will also discuss prospects of manipulating metal homeostasis to aid human health and environmental sustainability.
An introduction to the molecular and cellular processes common to life with an emphasis on control of energy and information flow. Central themes include metabolism, macromolecular function, and the genetic basis of cellular function. We examine how membranes work to establish the internal composition of cells; how the structure of proteins including enzymes affects protein function; how energy is captured, stored and utilized by cells; and how cells communicate, move and divide. We explore inheritance patterns and underlying molecular mechanisms of genetics, the central dogma of information transfer from DNA replication to protein synthesis, and recombinant DNA methods and medical applications. Laboratories include genetic analyses, enzyme reaction kinetics, membrane transport, and genomic analysis.COVID in the Classroom BIOL191: Student Reflections
Promoting public understanding of science has become more critical than ever in our society. In particular, there is a strong need for basic science education for young audiences. In this course, we discuss fundamental concepts in life science and skills for science literacy while exploring challenges in youth science education. We read articles on landmark biological discoveries, as well as literature on science education, science communication, and next-generation science standards for the target grade level to acquaint ourselves with the science background of target audience. As a Community-based Learning (CBL) experiential course, we directly engage with the local community by leading science activities at local public schools. Ultimately, this course aims to enhance students’ understanding of scientific and educational topics through community-based work, and to allow students to reflect in constructive ways on their experience working in the community and communicating science.